Gallery


January 10, 2025

Pyr into the brain.

Peep a few pyramidal neurons:

Thorny pyramidal neurons of hippocampus CA3

Pyr is all about pyramidal neurons, the primary excitatory neuron of the brain.

The brain can broadly be classified into volumes of grey and white matter. The surface volume of the brain commonly referred to as grey matter is scientifically called cortex. Cortex is where almost all cell bodies and synapses are found. If you go deeper into the brain, you get to white matter axonal highways.

Cortical column of pyramidal neurons from mouse visual cortex. IARPA MICrONS Explore

Above you can see a column of cells through the depth of cortex. Above the top is the surface of the brain. From Layer 1 at the top down to layer 6. The deeper cells are generally larger and are thought to project farther.

Check out the details on this giant Layer 5 Pyramidal neuron:

Pyramidal neurons with spiny dendrites shown. IARPA MICrONS
Pyramidal neuron at the top of a cortical column. IARPA MICrONS

Mossy fiber synapses found in Hippocampus CA3:

Excitatory thorny pyramidal neurons of hippocampus CA3. Yellow axon is an inhibitory cell that synapses with each soma.
Pyramidal neuron near and far
IARPA MICrONS https://www.microns-explorer.org/cortical-mm3